Dr Anna Fleming

Anna

Anna carried out a BSc in biochemistry at the University of Manchester and became intrigued by the management of gene expression and how its dysregulation could cause disease. She undertook a Master’s by Research in the lab of Prof. Stefan Roberts at the University of Bristol, investigating the role of cholesterol in the activity of the WT1 cofactor BASP1 and identifying a novel role for nuclear cholesterol in gene regulation.

In 2019, she moved to the University of Dundee, where she completed a CRUK-funded PhD in Dr Kasper Rasmussen’s lab. She identified the previously uncharacterised protein PROSER1 as a novel interacting partner of the DNA-demethylating TET enzymes and worked to characterise its role in TET function in haematopoiesis and development.

Anna moved to London in November 2024 and joined the Frost Lab as a Postdoctoral Associate, where she is working to characterise the precise roles of transposons as regulatory elements in placenta.

Outside of the lab, Anna spends most of her time cooking, drinking red wine and swing dancing.

Read Anna’s recent publication from the Rasmussen lab here:

Fleming et al., 2024 – PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations